首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Circadian rhythms of nocturnal hormones in rheumatoid arthritis: translation from bench to bedside
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Circadian rhythms of nocturnal hormones in rheumatoid arthritis: translation from bench to bedside

机译:类风湿关节炎夜间激素的昼夜节律:从板凳到床边的翻译

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摘要

Translation from basic research to clinical medicine is complex and needs to be carefully performed. In addition, transla-tional research is needed using human subjects who meet current diagnostic criteria. Recently, circadian. rhythm science has pointed the way to rational intervention on nocturnal hormone production to modulate the iramune/inflammatory reactions in patients suffering from rheumatoid arthritis (RA).'2 These approaches have been introduced into practice with increasing degrees of interest.3 We will discuss two recent examples of therapeutically modulating melatonin (MLT) and cortisol as nocturnal hormones implicated in RA clinical circadian rhythms#
机译:从基础研究到临床医学的翻译非常复杂,需要仔细进行。此外,需要使用符合当前诊断标准的人类受试者进行翻译研究。最近,昼夜节律。节奏科学指出了合理干预夜间激素产生的方法,可调节类风湿关节炎(RA)患者的免疫反应/炎症反应。'2这些方法已被引入实践,并且引起人们的关注。3我们将讨论两种方法调节褪黑素(MLT)和皮质醇作为夜间激素参与RA临床昼夜节律的近期例子#

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