Two new dihydrofuranoisoflavanones from the leaves of Lespedeza maximowiczi and their inhibitory effect on the formation of advanced glycation end products.

摘要

Two new dihydrofuranoisoflavanones, 2',4',5-trihydroxy-[5''-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2'',3'':7,8)] -(3S)-isoflavanone (1) and 2', 4', 5-trihydroxy-[5''-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2'',3'':7,8)]-(3R)- isoflavanone (2) as well as one already-known compound, (+)-catechin (3), were isolated from an n-BuOH soluble fraction from the leaves of Lespedeza maximowiczi. Spectroscopic data was used to elucidate the structures of compounds 1 and 2. All of the isolates were evaluated in vitro for their inhibitory activity on the formation of advanced glycation end products (AGEs). Among these, compounds 1, 2, and 3 exhibited inhibitory activity against AGEs formation with IC(50) values of 20.6, 18.4, and 5.6 microM, respectively.