Are anti-cyclic citrullinated peptide autoantibodies seromarkers for rheumatoid vasculitis in a cohort of patients with systemic vasculitis?

摘要

A diverse spectrum of vasculitic syndromes exists including systemic rheumatoid vasculitis (SRV), which sometimes occurs as the first manifestation of severe rheumatoid factor (RF)-positive rheumatoid arthritis. So far, no convincing laboratory parameter has been determined for the diagnosis of SRV, which helps in distinguishing rheumatoid vasculitis from other types of small-sized or medium-sized vessel vasculitides. The aim of our study was to estimate the potential diagnostic value of anti-cyclic citrullinated peptide (CCP) antibodies among the systemic vasculitides.