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Structure-activity relationship study of asiatic acid derivatives for new wound healing agent.

机译:新型伤口愈合剂积雪草酸衍生物的构效关系研究。

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摘要

Ten semi-synthetic derivatives of asiatic acid were prepared and their wound healing effects were evaluated by employing a tensile strength assay and a wound area assay. Among them, ethoxymethyl 2-oxo-3,23-isopropylidene-asiatate (12) showed the strongest and the fastest wound healing activity. Furthermore, it left the smallest scar after healing.
机译:制备了十个积雪草酸的半合成衍生物,并通过抗张强度试验和伤口面积试验评价了它们的伤口愈合效果。其中,乙氧基甲基2-氧代-3,23-异亚丙基-锡酸酯(12)显示出最强,最快的伤口愈合活性。此外,它在愈合后留下了最小的疤痕。

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