首页> 外文期刊>Archives of Environmental Contamination and Toxicology >Assessment of effects in mink caused by consumption of carp collected from the Saginaw River, Michigan, USA.
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Assessment of effects in mink caused by consumption of carp collected from the Saginaw River, Michigan, USA.

机译:评估从美国密歇根州萨吉诺河收集的鲤鱼食用对貂皮的影响。

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摘要

Polychlorinated hydrocarbons, including polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), are ubiquitous environmental contaminants that bioconcentrate in the food chain. Numerous studies have demonstrated mink (Mustela vison) to be one of the most sensitive species to this group of compounds. In recent studies, a lesion characterized by osteoinvasion of epithelial cells into the mandible and maxilla of young mink fed diets containing 3,3',4,4',5-pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was observed. The objective of the present study was to determine if proliferation of maxillary and mandibular squamous epithelia could be induced in ranch mink exposed to environmentally-derived polychlorinated hydrocarbons (PCBs, PCDDs, and PCDFs) in utero, during lactation, and throughout the growth period. Adult female mink were fed diets containing 0, 10, 20, or 30% carp (Cyprinus carpio) collected from the Saginaw River, Bay City, Michigan, USA, that provided 0.03, 0.83, 1.1, and 1.7 mg total PCBs (tPCBs)/kg feed and 2.5, 28, 47, and 73 ng TCDD toxic equivalents (TEQs)/kg feed, respectively, three weeks prior to breeding through weaning of the resulting offspring. Mink kits were maintained on their respective diets for up to 27 weeks of age. At 6 and 27 weeks of age, six to eight mink in each treatment group were necropsied and their jaws examined for evidence of maxillary and mandibular squamous epithelial proliferation. Results indicated that inclusion of up to 30% carp in the diet (1.7 mg tPCBs/kg feed, 73 ng TEQs/kg feed) had no effect on mink reproduction and kit survivability. However, maxillary and mandibular squamous epithelial proliferation was evident in four of the seven 27-week-old juveniles in the 20% carp group (1.1 mg tPCBs/kg feed, 47 ng TEQs/kg feed) and six of the eight juveniles in the 30% carp group (1.7 mg tPCBs/kg feed group, 73 ng TEQs/kg feed). Hepatic concentrations of tPCBs and TEQs increased in both the 6-week-old kits and the 27-week-old juveniles as the percentage of dietary carp increased. The livers of 6-week-old kits were also assessed for the presence of polybrominated diphenyl ethers, which increased as the percentage of Saginaw River carp in the diet increased.
机译:多氯烃,包括多氯联苯(PCBs),多氯二苯并对二恶英(PCDDs)和多氯二苯并呋喃(PCDF),是普遍存在于食物链中的环境污染物。大量研究表明,貂(Mustela vison)是对这组化合物最敏感的物种之一。在最近的研究中,一个病变特征在于上皮细胞向年轻的貂皮饲喂的日粮的下颌骨和上颌骨中侵入骨,其中含有3,3',4,4',5-五氯联苯(PCB 126)和2,3,7,8-四氯二苯并观察到对-二恶英(TCDD)。本研究的目的是确定是否可以在子宫内,泌乳期间以及整个生长期中,在暴露于环境衍生的多氯代烃(PCB,PCDDs和PCDFs)的水貂中诱导上颌和下颌鳞状上皮的增殖。成年雌性貂被喂食含有0%,10%,20%或30%鲤鱼的鲤鱼(Cyprinus carpio),这些鲤鱼是从美国密歇根州贝城的萨吉诺河收集的,提供了0.03、0.83、1.1和1.7 mg的多氯联苯(tPCBs) / kg饲料和2.5、28、47和73 ng TCDD毒性当量(TEQs)/ kg饲料,分别在通过断奶后代繁殖的三周之前。貂皮套件在各自的饮食中最多可维持27周龄。在6和27周龄时,对每个治疗组的6至8只貂进行尸检,并检查其颌骨,以寻找上颌和下颌鳞状上皮增生的证据。结果表明,日粮中添加最多30%的鲤鱼(1.7 mg tPCBs / kg饲料,73 ng TEQs / kg饲料)对貂的繁殖和成套件的存活率没有影响。但是,在20%鲤鱼组中,在27个27周龄的少年中,有四个上颌和下颌鳞状上皮增生很明显(1.1 mg tPCBs / kg饲料,47 ng TEQs / kg饲料)和八个少年中的六个30%鲤鱼组(1.7 mg tPCBs / kg饲料组,73 ng TEQs / kg饲料)。随着饮食鲤鱼百分比的增加,在6周龄试剂盒和27周龄幼鱼中,tPCBs和TEQs的肝脏浓度均增加。还评估了6周龄试剂盒的肝脏中多溴联苯醚的存在,其随着日粮中Saginaw河鲤鱼的百分比增加而增加。

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