Successful engraftment following umbilical cord blood transplantation for patients with HLA antibody with or without corresponding HLA in the transplanted cord blood.

摘要

Umbilical cord blood transplantation (CBT) from unrelated donors has increased recently for adult patients with hematological diseases who have no other suitable related or unrelated donors, as cord blood (CB) shows clinical characteristics, such as greater availability, shorter time for donor searches and less stringent requirements for HLA compatibility. However, primary graft failure or delayed neutrophil recovery are often encountered as significant problems. As the existence of HLA antibody has been thought to increase the risk of graft failure, patients with HLA antibodies may be excluded as candidates for CBT. Such patients also tend to be excluded as candidates for CBT because of the need for HLA-matched platelet transfusion. However, few reports have described the practical impact of HLA antibody in CBT. Here, we report two cases of successful engraft-ment following CBT for patients with HLA antibodies (Table 1).