首页> 外文期刊>Bone marrow transplantation >Transfusion of leukoreduced cellular blood components from cytomegalovirus-unscreened donors in allogeneic hematopoietic transplant recipients: analysis of 72 recipients.
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Transfusion of leukoreduced cellular blood components from cytomegalovirus-unscreened donors in allogeneic hematopoietic transplant recipients: analysis of 72 recipients.

机译:从异体造血移植受者中未经巨细胞病毒筛查的供体中白细胞减少的细胞血液成分的输注:72位受者的分析。

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摘要

Leukoreduction of blood components has been considered a safe alternative to screening donors for CMV. The objective of this study is to analyze the effectiveness of bedside leukoreduction in preventing CMV transmission. We retrospectively studied 72 transplant recipients and donors who were CMV-seronegative pairs. All patients were transfused with CMV-unscreened cellular blood products leukoreduced at the bedside using leukoreduction filters. Quality control measures performed monthly in our leukoreduced blood components consistently demonstrated that at least 95% of the units sampled meet the leukoreduction criterion established by the American Association of Blood Banks standards. The CMV status of the recipients and donors was determined before transplantation by the latex agglutination assay. Recipients were observed for at least 100 days after transplantation. CMV cultures of urine, buffy coat, bone marrow, and bronchial washings were done weekly when indicated. CMV antigenemia testing was performed twice weekly: 11 transplant recipients seroconverted after transplantation. One patient was positive for CMV antigenemia 4 months after transplantation, but did not have CMV infection. Two of 61 patients who were not seroconverted were CMV antigenemia positive and did not have CMV infection: leukoreduction of cellular blood products is an efficient method of preventing CMV infection.
机译:血液成分的白细胞减少已被认为是筛查CMV供体的一种安全替代方法。本研究的目的是分析床旁白细胞减少在预防CMV传播中的有效性。我们回顾性研究了CMV血清阴性对的72个移植受者和供体。使用白细胞减少过滤器向所有患者输注在床旁白细胞减少的CMV未筛选的细胞血液产品。我们对白细胞减少的血液成分每月进行的质量控制措施始终表明,至少有95%的采样单位符合美国血库协会标准制定的白细胞减少标准。在移植前通过乳胶凝集测定确定受体和供体的CMV状态。移植后至少100天观察到收件人。指示时,每周进行尿,血沉棕黄层,骨髓和支气管洗液的CMV培养。每周两次进行CMV抗原血症测试:11位移植受体在移植后发生血清转化。移植后4个月,一名患者的CMV抗原血症呈阳性,但未发生CMV感染。 61例未血清转化的患者中有2例是CMV抗原血症阳性且没有CMV感染:细胞血产物的白细胞减少是预防CMV感染的有效方法。

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