Eosinophilic cystitis following cord blood transplantation: a form of acute GVHD. A variant of hemorrhagic cystitis after hematopoietic SCT or drug-induced?

摘要

Eosinophilic cystitis (EC) is a rare inflammation of the bladder that manifests as grossly thickened, edematous bladder wall with mucosal erythema and areas of plaque or liberation on endoscopy. Histologically, EC involves transmural inflammation with a strong predominance of eosinophils in the bladder wall accompanied by fibrosis with or without muscle necrosis.1 Presentation is generally with urinary frequency, dysuria, urgency and hematuria.1 EC has not previously been reported in relation to hematopoietic stem cell transplantation (HST). Here, we describe an EC case following allogenic cord blood transplantation.A 45-year-old woman was admitted to our hospital due to relapsed acute myelomonocytic leukemia (World Health Organization classification). The patient had no specific symptoms on admission, and she had neither contributory family history nor any past history.