Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder

Ramos Eliana Marisa; Gillis Tammy; Mysore Jayalakshmi S.; Lee Jong-Min; Alonso Isabel; Gusella James F.; Smoller Jordan W.; Sklar Pamela; MacDonald Marcy E.; Perlis Roy H.

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Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder

机译：躁郁症患者亨廷顿舞蹈病基因CAG三核苷酸重复等位基因的患病率

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ObjectivesHuntington's disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. A greater than expected prevalence of incompletely penetrant HTTCAG repeat alleles observed among individuals diagnosed with major depressive disorder raises the possibility that another mood disorder, bipolar disorder, could likewise be associated with Huntington's disease.

机译：目的亨廷顿舞蹈病是一种神经退行性疾病，其特征是由亨廷顿基因（HTT）CAG三核苷酸重复等位基因等于或大于36个单位引起的运动，认知和精神症状。在诊断为重度抑郁症的个体中观察到的不完全渗透性HTTCAG重复等位基因患病率高于预期，增加了另一种情绪障碍（躁郁症）也可能与亨廷顿舞蹈病相关的可能性。

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《Bipolar disorders.》 |2015年第4期|共6页
作者
Ramos Eliana Marisa; Gillis Tammy; Mysore Jayalakshmi S.; Lee Jong-Min; Alonso Isabel; Gusella James F.; Smoller Jordan W.; Sklar Pamela; MacDonald Marcy E.; Perlis Roy H.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
bipolar disorder; depression; Huntington's disease; neurodegenerative disease; polyglutamine expansion; trinucleotide repeat;

机译：躁郁症;抑郁症;亨廷顿舞蹈病;神经退行性疾病;聚谷氨酰胺扩展;三核苷酸重复;

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1. Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder [J] . Ramos Eliana Marisa, Gillis Tammy, Mysore Jayalakshmi S., Bipolar disorders. . 2015,第4期

机译：躁郁症患者亨廷顿舞蹈病基因CAG三核苷酸重复等位基因的患病率
2. A Unified Rapid PCR Method for Detection of Normal and Expanded Trinucleotide Alleles of CAG Repeats in Huntington Chorea and CGG Repeats in Fragile X Syndrome [J] . Tihomir Todorov, Albena Todorova, Bilyana Georgieva, Molecular Biotechnology . 2010,第2期

机译：统一的快速PCR方法检测亨廷顿舞蹈病中CAG重复序列和脆性X综合征中CGG重复序列的正常和扩展三核苷酸等位基因
3. A unified rapid PCR method for detection of normal and expanded trinucleotide alleles of CAG repeats in Huntington Chorea and CGG repeats in Fragile X syndrome [J] . Todorov T., Todorova A., Georgieva B., Molecular biotechnology . 2010,第2期

机译：一种统一的快速PCR方法，用于检测Huntington Chorea中CAG重复序列的正常和扩展三核苷酸等位基因以及脆性X综合征中CGG重复序列
4. Copy Number Variation, Eicosapentaenpic Acid and Neurological Disorders: With Particular Reference to Huntington's Disease and Associated CAG Repeats, and to Myalgic Encepliaiomyelitis and Viral Infec [C] . Basant K. Puri, Mehar S. Manku Congress of the International Society of Nutrigenetic/Nutrigenomics . 2010

机译：拷贝数变异，eicosapentaenpic酸和神经疾病：特别参考亨廷顿的疾病和相关的CAG重复，以及肌algicenceplia肌炎和病毒infec
5. Cloning of candidate genes for bipolar disorder starting from expanded trinucleotide repeats. [D] . Goossens, Dirk. 2001

机译：从扩大的三核苷酸重复序列开始克隆双相情感障碍的候选基因。
6. Expanded CAG trinucleotide repeat of Huntingtons disease gene in a patient with schizophrenia and normal striatal histology. [O] . D St Clair 1994

机译：在患有精神分裂症和正常纹状体组织学的患者中亨廷顿氏病基因的CAG三核苷酸重复序列扩大。
7. Expanded CAG trinucleotide repeat of Huntington's disease gene in a patient with schizophrenia and normal striatal histology. [O] . St Clair, D 1994

机译：在患有精神分裂症和正常纹状体组织学的患者中，亨廷顿氏病基因的CAG三核苷酸重复序列扩大。

Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder

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