Severe pulmonary toxoplasmosis after allo-SCT in two patients: from Toxoplasma genotyping to clinical management.

摘要

Toxoplasma gondii infection can be a devastating disease in immunodeflcient individuals. In these patients (AIDS, organ transplantation), severe toxoplasmosis can result mainly from reactivation of a latent infection. It can induce symptoms restricted to the central nervous system, lung, heart and eyes or cause disseminated infection. Although severe toxoplasmosis is a rare but often fatal event, disease severity and outcome might be influenced by parasite genotype.2 We report two cases of toxoplasmosis in haematopoietic SCT (HSCT; allo-SCT) patients, associated with non-type II strains of T. gondii. Susceptibility to toxoplasmosis of such non-HIV-immuno-compromised patients is discussed in terms of underlying disease, toxoplasmosis prevention, clinical features, undergoing treatment and the potential role of the T. gondii genotype.