UNCOUPLING PROTEINS AND SLEEP DEPRIVATION C

摘要

Fifteen years ago Michel Jouvet showed that in pontile cats, who are poikilother-mic, central temperature is the principal factor that regulates the quantity of paradoxical sleep (PS), its ultradian periodicity, as well as the duration of PS episodes (17). Ten years later, Jouvet and colleagues also showed that PS is exquisitely sensitive to conditions that impair oxidative metabolism, and linked the positive effect of hypothermia on PS to its ability to reduce metabolic rate, and to protect the brain against hypoxic alterations and oxidative stress (1). A few months ago, in occasion of the meeting held in Lyon in his honor, Michel Jouvet strongly maintained that the link between sleep regulation, energy metabolism, and thermoregulation should be further explored, because it may hold important clues relative to the functions of sleep. Below is the first study by our laboratory to address this issue, and we dedicate this work to Prof. Jouvet. The paper shows that sleep deprivation has profound effects on the expression of uncoupling proteins, which play a major role in thermoregulation, as well as in the response to oxidative stress.