In children, does the use of higher-fl uoride toothpaste compared with lower-fl uoride toothpaste or placebo reduce the incremental development of dental caries, and do baseline caries or supervised brushing infl uence the effect?Selected studies were randomised controlled trials (RCT) or cluster RCT in which children were randomly assigned to fl uorideon-fl uoride groups or to fl uoride groups of different concentrations and were followed up for 12 months or more.
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