No association between asthma or allergy and the CCR5Delta 32 mutation.

摘要

AIMS: To investigate whether the presence of the CCR5Delta32 allele was associated with atopy or asthma. METHODS: A total of 118 children with asthma, 145 children with non-asthmatic, but allergic phenotype, and 303 children without allergic or asthmatic disorders were studied. RESULTS: There were no significant differences in the frequency of CCR5Delta32, or in the distributions of genotypes between the groups. The relative eosinophil blood count was slightly lower in patients with heterozygous genotype, than in patients with wild type genotype. CONCLUSION: No association was found between the susceptibility of allergy or asthma and the functional deficient CCR5Delta32 allele.