Is scoliosis an issue for giving growth hormone to children with Prader-Willi syndrome?

摘要

Prader-Willi syndrome (PWS) is a rare genetic disorder with a large range of severe co-morbidities including severe neonatal hypotonia with failure to thrive and dys-morphic features during the first months of life followed by the development of morbidobesity and endocrine disorders related to hypothalamic dysfunction (growth hormone (CH) deficiency, hypogonadism, oxy-tocin deficiency) associated with learning disabilities and behavioural and psychiatric problems.12 Early diagnosis combined with multidisciplinary care, parental guidance and GH treatment prevent precocious and morbid obesity in most cases.3Since optimisation of the management of obesity and other endocrine disorders in these children, experts now have to deal with other pathological conditions that were less often reported when morbid obesity was the biggest challenge.