Advanced glycation end products induced immune maturation of dendritic cells controls heart failure through NF-kappa B signaling pathway

摘要

Background and aims: It is commonly believed that diabetes is an important contributor to heart failure (HF) development. However, the detail effect of diabetogenesis on HF is controversy: both beneficial and harmful roles were reported. In the present study, we aim to explore the unambiguous action of diabetes on chronic HF progression and the underlying mechanism.