Yersinia pseudotuberculosis causing abscesses in a 31-year-old patient in the post-immunosuppression period after allogeneic HSCT.

摘要

The risk of infection after allo-SCT is determined by the underlying disease, intensity of earlier treatments and by the chosen transplantation modality. High risk of infection even after hematopoietic reconstitution is characteristic compared with patients undergoing conventional chemotherapy or auto-SCT. On account of mucosal damage, functional deficiencies of granulocytes, functional asplenia and qualitative and quantitative T- and B-cell deficiencies, late infections after allo-SCT (after day +100 following transplantation) predominate in patients with chronic GVHD. In the absence of GVHD, immunosuppressive treatment is tapered and finally discontinued. In these patients, infectious complications are supposed to occur rarely. We describe a patient who underwent HLA-mismatched, unrelated allo-SCT because of bcr-abl-posi-tive ALL and developed severe hepatic abscesses after immunosuppression had been discontinued 1 year earlier.