Synthesis of 1,2,3-triazolyl nucleoside analogs as potential anti-influenza A (H3N2 subtype) virus agents

摘要

Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2/KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2). A series of 1,2,3-triazolyl nucleoside analogs were synthesized using a heterogeneous catalyst (CuCl2/KI/K10) and evaluated for their antiviral activities. Compound 18 was the most promising agent against influenza virus A (subtype H3N2).