(Gd,Yb,Tb)PO4 up-conversion nanocrystals for bimodal luminescence-MR imaging

摘要

Up-conversion (Gd,Yb,Tb)PO4 materials and their potential for bimodal imaging have received little attention in the literature. Herein, we report the first study on the up-conversion emission of (Gd,Yb,Tb)PO4 nanocrystals synthesized via a hydrothermal method at 150 ℃. These materials exhibit ultraviolet, blue and green up-conversion emissions upon excitation with a 980 nm continuous wave laser diode. The intensity of the blue-emission band at 479 nm, ascribed to the cooperative up-conversion emission of a pair of excited Yb~(3+) ions, depends on the Yb~(3+)/Tb~(3+) concentration ratio, calcination temperature and particle size. Strong green up-conversion emission of Tb~(3+) is observed at 543 nm for the ~5D4 → ~7F5 transition. Relaxometry measurements reveal that the nanocrystals are efficient T2-weighted (negative) contrast agents which, combined with visible-light emission generated by infrared excitation, affords them considerable potential for being used in bimodal, photoluminescence-magnetic resonance, imaging.