A Scalable, Efficient Gold-Catalyzed Oxidative Phosphonation of sp~3 C-H Bonds using Air as Sustainable Oxidant

摘要

A scalable, efficient gold-catalyzed oxidative phosphonation of sp~3 C—H bonds with various diarylphosphine oxides and dialkyl phosphites has been developed by using air as a sustainable oxidant under mild reaction conditions. It provides an easy access to α-amino phosphonic compounds in high yields with a broad reaction scope. The safe, convenient and environmentally benign process makes this protocol very promising.