Au(I)-Catalyzed sp~3 C-H Bond Insertion: A New Aspects from Au(I)-Catalyzed Cycloisomerization of 1,5-Enynes

摘要

Gold carbenoids generated from 1,5-enyries and propargyl esters are emerged as a potential in place of the reaction of diazocompounds with transition metal complex, since such methodology provides mild reaction condition and is able to handle in safe. While several applications of gold carbenoid for organic transformations, olefin cyclopropanation, Rautenstrauch rearrangement and oxidative rearrangement, have been appeared, exploration of the nature of gold carbenoid for the sp~3 C-H insertion reaction has not been developed. To aim of developing of gold carbenoid for the sp~3 C-H insertion, our attention has been paid to 1,5-enyne systems A, because we postulated that highly flexible ring close to gold carbenoid intermediate C would allow to give the opportunity for the C-H insertion of gold-carbenoid.