Copper(I)-Catalyzed Stereoselective Synthesis of (E)-alpha-Alkynyl-alpha,beta-unsaturated Esters from a Terminal Alkyne, Diazoesters and Aldehydes

摘要

A new synthetic method for alpha-alkynyl-alpha,beta-unsaturated esters is presented herein. The method is based on a copper(I)-catalyzed three-component reaction of a terminal alkyne, diazoesters and aldehydes. The reaction is featured by mild conditions, high yields and excellent stereoselectivity. Cu(I) car-bene migratory insertion is proposed as the key step in the transformation.