Organocatalytic anti-Msamich Reactions with Dihydroxyacetone and Acyclic Dihydroxyacetone Derivatives;A Facile Route to Amino Sugars

摘要

The first primary amine-containing amino acid-catalyzed anti-Mannich reactions of dihydroxyacetone and acyclic dihydroxyacetone derivatives with a variety of imines have been developed.This approach complements proline-based strategies in the preparation of amino sugars.Amino and imino sugars are of significant interest not only for use as tools in glycobiology but also for the treatment of a range of human diseases ranging from HIV-1 and hepatitis C infections to genetic disorders like Gaucher's disease and other inborn errors of metabolism.