Risk factors in heart disease: therapeutic interventions.

摘要

Many investigators continue to labor assiduously to elucidate the seemingly endless operant conditions resulting in cardiovascular disease. In aggregate, this work continues to categorize the complex sets of responses of the cardiomyocyte to noxious stimuli. This Forum aims to explore newer concepts and mechanisms contributing to heart tissue injury as well as presenting potential therapeutic strategies by highlighting the work of several laboratories currently engaged in examining nontraditional risk factors and potentially new directions in treatment. In particular, many of the articles presented revolve around two increasingly real threats to heart health from a population perspective: obesity and diabetes. These two conditions present formidable problems not only in the developed world but also globally (20). Addressing these threats requires a deep understanding of the socioeconomic, environmental, and biologic causal factors along with extensive dissemination of data and coordination of investigative activities across all relevant domains.