Catalytic Enantioselective Michael Reaction of 1,3-Dicarbonyl Compounds via Formation of Chiral Palladium Enolate

摘要

An efficient catalytic enantioselective Michael reaction has been developed using chiral palladium complexes.Various substrates including beta-keto esters and 1,3-diketones reacted with alpha,beta-unsaturated carbonyl compounds to give the corresponding Michael adducts in good yield with up to 99% ee,thereby affording chiral quaternary carbon centers.In these reactions,chiral palladium enolates were generated as key intermediates,which acted cooperatively with a strong protic acid to activate the Michael acceptors for promotion of the C-C bond-forming reaction.