Differential expression of MMP-2 and MMP-9 activity in megakaryocytes and platelets.

摘要

In the May 31,2011 online issue of Blood, Cecchetti et al presented a transcriptome analysis of matrix metalloproteinase (MMP) expression in megakaryocytes and platelets.1 Their results demonstrate that megakaryocytes and platelets differentially express mRNAs and proteins for MMPs. The authors found that platelets constitutively expressed MMP-2 protein and released it on throm-bin activation, although platelets lacked mRNA for MMP-2. On the other hand, they did not detect pro-MMP-9 protein in both inactivated and thrombin-stimulated platelet lysates, even though MMP-9 mRNA was present; moreover, the authors also detected MMP activity in megakaryocyte releasates but not in their lysates.