Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae.

Jacoby GA; Mills DM; Chow N

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Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae.

机译：β-内酰胺酶和孔蛋白在肺炎克雷伯菌中对ertapenem和其他β-内酰胺的抗性中的作用。

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High-level resistance to ertapenem was produced by beta-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 microg/ml and expression of outer membrane proteins was diminished could be selected.

机译：第1组，第2f组和第3组的β-内酰胺酶在缺乏Omp35和Omp36的肺炎克雷伯菌中产生了对ertapenem的高水平抗性。从产生ACT-1β-内酰胺酶的野生型菌株中，可以选择ertapenem MICs高达128 microg / ml且外膜蛋白表达减少的抗ertapenem突变体。

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《Antimicrobial agents and chemotherapy.》 |2004年第8期|共4页
作者
Jacoby GA; Mills DM; Chow N;
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正文语种 eng
中图分类药学;
关键词
Cancer resistance to treatment; beta-Lactamases; Klebsiella pneumonia bacterium; β内酰胺酶类; 角色;

机译：Cancer resistance to treatment;beta-Lactamases;Klebsiella pneumonia bacterium;β内酰胺酶类;角色;

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1. Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae. [J] . Jacoby GA, Mills DM, Chow N Antimicrobial agents and chemotherapy. . 2004,第8期

机译：β-内酰胺酶和孔蛋白在肺炎克雷伯菌中对ertapenem和其他β-内酰胺的抗性中的作用。
2. Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae. [J] . Martinez Martinez-L, Pascual A, Hernandez Alles-S, Antimicrobial agents and chemotherapy. . 1999,第7期

机译：β-内酰胺酶和孔蛋白在碳青霉烯类和头孢菌素类抗肺炎克雷伯菌中的作用。
3. Outer membrane protein alterations and blaTEM-1 variants: their role in beta-lactam resistance in Klebsiella pneumoniae. [J] . Nelson EC, Segal H, Elisha BG The Journal of Antimicrobial Chemotherapy . 2003,第6期

机译：外膜蛋白改变和blaTEM-1变体：它们在肺炎克雷伯菌的β-内酰胺抗性中的作用。
4. A FLUORESCEIN-LABELED BETA-LACTAMASE MUTANT FOR HIGH-THROUGHPUT SCREENING OF BACTERIAL BETA-LACTAMASES AGAINST BETA-LACTAM ANTIBIOTICS [C] . . 2005

机译：荧光素标记的β-内酰胺酶突变体，用于抗β-内酰胺的细菌β-内酰胺酶的高通量筛选
5. Protein engineering of class A and C beta-lactamases for beta-lactam antibiotic detection. [D] . Tsang, Man Wah. 2007

机译：A和C类β-内酰胺酶的蛋白质工程技术，用于检测β-内酰胺类抗生素。
6. Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniae. [O] . G A Papanicolaou, A A Medeiros, G A Jacoby 1990

机译：新型质粒介导的β-内酰胺酶（MIR-1）赋予肺炎克雷伯菌临床分离株中的氧亚氨基和α-甲氧基β-内酰胺类耐药性。
7. Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniae. [O] . Papanicolaou, G A, Medeiros, A A, Jacoby, G A 1990

机译：新型质粒介导的β-内酰胺酶（MIR-1）赋予肺炎克雷伯菌临床分离株中的氧亚氨基和α-甲氧基β-内酰胺类耐药性。

Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae.

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