Post-elution concentration of (TcO4-)-Tc-99m by a single anion exchanger column I: Feasibility of extending the useful life of column chromatographic Tc-99m generator

摘要

Tc-99m eluate in 0.7/0.35 M acetic acid and in 1 : 1 v/v 0.7 M acetic acid: 0.025 M ammonium acetate (30-40 ml) was conveniently concentrated by passing through a small column of a readily available weak anion exchanger, DEAE cellulose, (200 mg, 6 x 8 mm) and subsequent elution with 3 ml normal saline, with greater than 90% recovery. The quality of pertechnetate thus obtained and its compatibility for preparing Tc-99m compounds were satisfactory. This method was successfully applied to the alumina column chromatographic generator produced in-house and to a commercial Mo-99-Tc-99m generator after extensive clinical use. Potential for much higher concentration factors with compacted anion exchanger cartridges as well as applicability for W-188-Re-188 generator are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved. [References: 12]