Post-elution concentration of ~(99m)TcO_(4)~(-) by a single anion exchanger column I: Feasibility of extending the useful life of column chromatographic ~(99m)Tc generator

摘要

~(99m)Tc eluate in 0.7/0.35 M acetic acid and in 1:1 v/v 0.7 M acetic acid: 0.025 M ammonium acetate (30-40 ml) was conveniently concentrated by passing through a small column of a readily available weak anion exchanger, DEAE cellulose, (200 mg, 6×8 mm) and subsequent elution with 3 ml normal saline, with greater than 90% recovery. The quality of pertechnetate thus obtained and its compatibility for preparing ~(99m)Tc compounds were satisfactory. This method was successfully applied to the alumina column chromatographic generator produced in-house and to a commercial ~(99)Mo-~(99m)Tc generator after extensive clinical use. Potential for much higher concentration factors with compacted anion exchanger cartridges as well as applicability for ~(188)W-~(188)Re generator are discussed.