Low Temperature Synthesis of No-carrier-added [↑(11)C]formaldehyde with Metal Hydrides and Preparation of [1-↑(11)C] 1,2, 3,4-Tetrahydro-β-Carboline Derivatives

M. W. NADER; S. K. ZEISLER; A. THEOBALD

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Low Temperature Synthesis of No-carrier-added [↑(11)C]formaldehyde with Metal Hydrides and Preparation of [1-↑(11)C] 1,2, 3,4-Tetrahydro-β-Carboline Derivatives

机译：金属氢化物的低温合成无载体的[↑（11）C]甲醛及其制备方法[1-↑（11）C] 1,2,3,4-四氢-β-咔啉衍生物

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A comparative study has been performed on the selective reduction of cyclotron-produced [↑(11)C]carbon dioxide to [↑(11) C]formaldehyde with solutions of various complex metal hydrides at temperatures between -52 and +25℃. Under optimal reaction conditions, lithium tetrahydridoaluminate gave the highest yield of [↑(11)C]formaldehyde (58%, decay-corrected), followed by lithium triethylhydridoborate (34%) and sodium tetrahydridoborate (22%). Radiochemically pure [↑(11)C]formaldehyde could be obtained with lithium tetrahydridoaluminate and sodium tetrahydridoborate, but not with lithium triethyl hydridobo-rate. The produced [↑(11)C]formaldehyde was used for the synthesis of [l-↑(11)C]l,2,3,4-tetrahydro-β-carbo-line derivatives by the Pictet-Spengler reaction. # 1998 Elsevier Science Ltd. All rights reserved

机译：已经进行了比较研究，研究了在-52至+25℃之间用各种复杂的金属氢化物溶液将回旋加速器产生的[↑（11）C]二氧化碳选择性还原为[↑（11）C]甲醛。在最佳反应条件下，四氢铝酸锂的最高产率是[↑（11）C]甲醛（58％，经衰减校正），其次是三乙基氢硼酸锂（34％）和四氢硼酸钠（22％）。用四氢铝酸锂和四氢硼酸钠可制得放射化学纯的[↑（11）C]甲醛，而用三乙基氢硼酸锂则不能制得。所产生的[↑（11）C]甲醛用于通过Pictet-Spengler反应合成[1-↑（11）C] 1,2,3,4-四氢-β-咔啉衍生物。＃1998 Elsevier Science Ltd.保留所有权利

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine 》 |1998年第12期| 共5页
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M. W. NADER; S. K. ZEISLER; A. THEOBALD;
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中图分类原子核物理学、高能物理学 ; 放射医学 ;
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1. Low Temperature Synthesis of No-carrier-added [↑(11)C]formaldehyde with Metal Hydrides and Preparation of [1-↑(11)C] 1,2, 3,4-Tetrahydro-β-Carboline Derivatives [J] . M. W. NADER, S. K. ZEISLER, A. THEOBALD Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 1998 ,第12期

机译：金属氢化物的低温合成无载体的[↑（11）C]甲醛及其制备方法[1-↑（11）C] 1,2,3,4-四氢-β-咔啉衍生物
2. Aza-Annulation of 1,2,3,4-Tetrahydro-β-carboline Derived Enaminones and Nitroenamines: Synthesis of Functionalized Indolizino[8,7-b]indoles, Pyrido[1,2-a:3,4-b′]diindoles, Indolo[2,3-a]quinolizidine-4-ones and Other Tetrahydro-β-carboline Fused Heterocycles [J] . Anusha Avadhani, Pethaperumal Iniyavan, Anand Acharya, ACS Omega . 2019 ,第18期

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7. One-pot rapid and efficient synthesis of new spiro derivatives of 11H-indeno[1,2-b]quinoxalin-11-one, 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one and isatin-based 2-pyrazolines [O] . Javad Azizian, Masoud Shaabanzadeh, Farhad Hatamjafari, 2006

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Low Temperature Synthesis of No-carrier-added [↑(11)C]formaldehyde with Metal Hydrides and Preparation of [1-↑(11)C] 1,2, 3,4-Tetrahydro-β-Carboline Derivatives

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