The pathophysiology of FNAIT cannot be deduced from highly selected retrospective data.

摘要

Today there is no consensus regarding the optimal method for determining the fetal status when the mother has alloantibod-ies against fetal platelets. Therefore, it was with great interest we read the article by Bertrand et al recently published in Blood. However, we feel that a few points need to be clarified by the authors.The study included 75 women who underwent 239 pregnancies complicated by fetal and neonatal alloimmune thrombocytopenia (FNATT). Given the same frequency of FNATT in France as in Norway, the yearly expected number of newborns with FNAIT in France would be between 400 and 700. It is surprising that the authors report only the result of 155 pregnancies in Table 2. This represents 0.8%-1.4% of the total number of FNAIT cases occurring in France and 4.7%-8.5% of all FNAIT cases in Paris. Furthermore, of the 75 women who were studied, we were puzzled to discover the authors present antibody values at delivery from only 30 of these women.