PRCP regulates angiogenesis in vivo.

摘要

Angiogenesis, the process by which new blood vessels are generated during development, has a critical role in solid tumor progression and hematological malignancies. Understanding how druggable proteins regulate this complex process is crucial for the development of new pharmacological leads for anticancer therapy. The PRCP gene encodes for a serine protease that generates plasma kallikrein from prekallikrein and degrades angiotensin II and alpha-melanocyte-stimulating hormone (alpha-MSH) by proteolyzing their C-terminal Pro-X bonds.