Coexistent Isolated Tumor Cell Clusters of Infiltrating Lobular Carcinoma and Benign Glandular Inclusions of Mullerian (Endosalpingiosis) Type in an Axillary Sentinel Node: Case Report and Review of the Literature

摘要

Abstract: The presence of benign epithelial inclusions in axillary lymph nodes coexistant with breast disease is a rare event; however, their presence makes the assessment of nodal disease diagnostically challenging. Broadly, these inclusions can be classified as glandular (mullerian type or nonmullerian type), mixed glandular-squamous, and squamous. Among these the presence of benign mullerian-type glandular inclusions with concurrent breast parenchymal disease is an exceedingly rare event, with 10 previous cases reported in the literature, 2 coexisting with infiltrating ductal-type mammary carcinoma in axillary lymph nodes. Here, we report the first case of coexistent invasive lobular carcinoma and endosalpingiosis in an axillary lymph node. The presence of benign epithelial inclusions in axillary lymph nodes is a rare event. The epithelial inclusions can be classified as glandular (mullerian or nonmullerian type), mixed glandular-squamous, and squamous.1 Benign mullerian-type glandular inclusions with coexistent breast parenchymal disease are exceedingly rare, with 10 previous cases reported in the literature, 2 coexisting with infiltrating ductal-type mammary carcinoma (Table 2).Here, we report the first case of coexistent invasive lobular carcinoma and endosalpingiosis in an axillary lymph node. The patient is an 86-year-old female who was referred to our institution for a nonpalpable, upper outer quadrant, 5-mm spiculated mass of the left breast.