DNA-mediated site-specific deposition of gold nanoparticles on silicon wafers

摘要

We report a method for the site-specific deposition of gold nanoparticles, as programmed by DNA sequences immobilized on the surface of silicon oxide-coated silicon wafers. After optimization of surface chemistries, selectivities of between 8 :1 and 118 :1 were achieved for the DNA-based sorting of populations of gold nano-particle of 15 nm and 60 nm diameter from a common suspension via oligonucleotide duplex formation.