Importance of animal research in zoonoses

摘要

Pound and Bracken's observations on the failure of animal research to translate evidence to humans stem mostlyfrom poordesign and conduct of animal research. These observations, however, do not apply to zoonotic diseases, which infect multiple species and constitute more than 60% and 75% of known and emerging infectious diseases, respectively.The causes, risks, and treatment of zoonotic diseases are similar across multiple species. Treatment efficacy is also thought to be similar across multiple species, so it is prudent to demand scientifically valid evidence from animal experiments that is applicable to multiple species, including humans. A paucity of evidence from animal experiments will greatly affect not only humans but also multiple species.