Rapid Evaluation of Critical Reactions Supporting Contract Research and Manufacturing

摘要

Uniqsis,in conjunction with their exclusive USA distributor,Sentinel Process Systems,Inc,reports how a FlowSyn~TM continuous flow reactor installed at Adesis Inc is assisting them in evaluating custom synthetic routes for compounds along with improving existing batch manufacturing processes.Dr Hai Le,who leads the Adesis Flow Chemistry Group,said:"My group uses the Uniqsis FlowSyn for the evaluation of the best routes in terms of yield and economics for compounds of critical importance to our customers.Our approach is to evaluate hundreds of potential reaction pathways quickly and repeatably,always looking to provide the greatest value to our customers.Our ability to quickly identify the maximum value path is supported by the versatility of the Uniqsis FlowSyn family of products that enable tens of reactions per day that vary temperature,residence time and mole ratio by simply entering these parameters into a keypad and letting the automated FlowSyn system provide continuous product samples ready for analysis.In particular,the GAM allows for the rapid change-out to and from using reactive gases.No other tool on the market allows for this level of speed and versatility when evaluating gas-liquid reactions.The addition of the Uniqsis FlowSyn tool suite has enabled us to support the needs of our customers whose requirements for cost,quality and speed to market are of the utmost concern.Most recently,we successfully developed a critical flow process for a commercial-ready-chemical.The flow method doubles the overall yield,minimises stoichiometry of a starting material which require multiple synthetic steps to obtain,while decreasing by-product formation from 30% to 0.2%.This process can be scaled up to deliver hundreds of grams per day reproducibly.