Clinicopathological features of patients with Borrmann typeIV gastric carcinoma.

摘要

BACKGROUND: To determine whether there is a specific pattern ofclinicopathological features that could be used to distinguish -Borrmanntype IV gastric carcinoma from other types of gastric carcinoma. METHODS: We retrospectively analysed the clinicopathologicalfeatures of patients with Borrmann type IV carcinoma of the stomach.The results were compared with the features of patients who hadother types of gastric carcinoma. RESULTS: The incidence of Borrmann type IV gastric carcinomawas 11.0% (199 patients). A poorly differentiated tumourwas found in 120 out of 199 patients (60.3%) with Borrmanntype IV gastric carcinoma. The positive lymph node metastasis wasfound in 150 out of 199 patients (75.4%) with Borrmanntype IV gastric carcinoma (P < 0.0001).The incidence of serosal invasion (91.5%) and peritonealdissemination (37.7%) was significantly higher in thesepatients. Of the patients with Borrmann type IV gastric carcinoma,161 patients (80.9%) were classified as either stage IIIor IV at initial diagnosis. The curative resection rate of patientswith Borrmann type IV gastric carcinoma was lower than that of patientswith other types of gastric carcinoma (P < 0.001).The survival rate was higher in patients with a curative resection(P < 0.001). The 5-year survivalrate of patients with Borrmann type IV tumour was lower than thatof patients with other types of gastric carcinoma (P < 0.001).The 5-year survival rates were 90.9% for stage I patientswith Borrmann type IV gastric carcinoma and 39.5%, 18.6% and8.7% for stages II, III and IV, respectively (P < 0.001). CONCLUSION: Improving the prognosis for patients with Borrmanntype IV gastric carcinoma requires early detection and a curative resection.