A Green Catalyst Fe(OTs)3/SiO2 for theSynthesis of 4-Pyrrolo-12-oxoquinazolines

摘要

An efficient and eco-friendly diversity-oriented synthetic protocol has been presented to synthesize structurally versatile drug-like molecules under solvent-free grinding in the presence of Fe(OTs)3/SiO2 as a catalyst.The use of Fe(OTs)3/SiO2 as a recyclable and reusable catalyst has been explored in the synthetic domino protocol involving one-pot,three component reaction for the synthesis of 4-pyrrolo-12-oxoquinazolines with special features of the protocol like high atom-economy,operational simplicity,short reaction time and high selectivity with excellent yields.