Recent Applications of Asymmetric Organocatalytic Methods in Total Synthesis

摘要

Natural products are the great sources of drugs and leading compounds in drug discovery, as it has been estimated that most of the current medicines are derived from natural products. Total synthesis of natural products, especially those of biological activities, has been an important part of organic chemistry, which, besides its potential practical utilities, also provides new inspirations and novel synthetic methodologies. Over the past two decades, organocatalysis has been shown to be very effective in controlling the stereochemistry of the reaction products and has found many applications in the asymmetric synthesis of natural products and related com- pounds. In this review we will attempt to summarize some applications of asymmetric organocatalysis in the total syn- thesis of natural products and related compounds in the past seven years.