Catalytic Asymmetric Formal Total Synthesis of(-)-Triptophenolide and(+)-Triptolide

摘要

Catalytic asymmetric formal synthesis of(-)-Triptophenolide and(+)-Triptolide have been achieved.Key reaction involves Palladium catalyzed asymmetric conjugate addition of aryl boronic acid to 3-methyl cyclohexe-1-none to form quaternary carbon.Claisen rearrangement and subsequent aldol reaction furnished trans-decaline key intermediate,which assured a formal total synthesis of(-)-Triptophenolide and(+)-Triptolide.