A Valuable Method for the Synthesis of 2-Benzylchromones:A Comparative Evaluation of Both Conventional and Microwave-Assisted Synthesis

摘要

Chromones(4H-chromen-4-ones)contemplate a naturally occurring class of compounds widely distributed in Nature,particularly in plants.This singular ring system has emerged as a privileged scaffold in medicinal chemistry,mainly due to its unique structural features,diverse biological activities,and pharmacological properties.Throughout the past few years,our efforts have been focused on synthesizing a series of 2-benzylchromones through a Claisen condensation,using 2'-hydroxyacetophenones and ethyl 2-phenylacetates.However,the extended periods of reaction necessary for the synthesis of 2-benzylchromones led to the search for an alternative.Thus,microwave irradiation emerged as a suitable approach to obtain these chromones in shorter reaction times and with similar or even improved synthetic yields.Our work demonstrates that it is possible to synthesize 2-benzylchromones through both conventional and microwave-assisted synthesis,favoring the use of microwave irradiation.