THE PEPTOID SYNTHESIS FROM SOME AMINO ACID ANALOGS

摘要

Oligomeric N-substitued glycines(NSG)or "peptoids" are a novel class of polymer.In this study, four submonomers were synthesized for novel NSGs.These are 2- [(Triisopropylsilyl)oxy]ethylamine,Butyloxycarbonyl(Boc)-l,4-diaminobutane,sec-Butylamine,iso-Butylamine.These submonomers were successfully used for the preparation of oligo-peptoids by the conventional submonomer synthesis method.Peptoids or oligomers of N-substitued glycines which are not found in nature are a new class of polymers.Peptoids are based on a polyglycine backbone,in which the side chains are pendant groups of amide nitrogen rather than the a-carbon.Our purpose was to design,synthesize,purify and characterize the biophysical activity of polypeptoid-based biomimetics as hexamer peptoids which can replace important proteins in the body such as two lung surfactant proteins(SP-B and SP-C).