MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-kappa B pathway in LPS-challenged HUVECs and septic mice

摘要

Aims: Sepsis is a systemic inflammatory complication, which is the common cause of death in critical patients. This study aimed to evaluate the potential regulatory mechanisms of miR-150 in lipopolysaccharide (LPS)-challenged HUVECs and cecal ligation and puncture (CLP)-induced septic mice.