Investigation of the mechanical properties of a bony scaffold for comminuted distal radial fractures: Addition of akermanite nanoparticles and using a freeze-drying technique

摘要

One of the methods of repairing the damaged bone is the fabrication of porous scaffold using synergic methods like three-dimensional (3D) printing and freeze-drying technology. These techniques improve the damaged and fracture parts rapidly for better healing bone lesions using bioactive ceramic and polymer. This research, due to the need to increase the mechanical strength of 3D bone scaffolds for better mechanical performance. Akermanite bioceramic as a bioactive and calcium silicate bioceramic has been used besides the polymeric component. In this study, the porous scaffolds were designed using solid work with an appropriate porosity with a Gyroid shape. The prepared Gyroid scaffold was printed using a 3D printing machine with Electroconductive Polylactic Acid (EC-PLA) and then coated with a polymeric solution containing various amounts of akermanite bioceramic as reinforcement. The mechanical and biological properties were investigated according to the standard test. The mechanical properties of the porous-coated scaffold showed stress tolerance up to 30 MPa. The maximum strain obtained was 0.0008, the maximum stress was 32 MPa and the maximum displacement was 0.006 mm. Another problem of bone implants is the impossibility of controlling bone cancer and tumor size. To solve this problem, an electroconductive filament containing Magnetic Nanoparticles (MNPs) is used to release heat and control cancer cells. The mechanical feature of the porous scaffold containing 10 wt% akermanite was obtained as the highest stress tolerance of about 32 MPa with 46% porosity. Regarding the components and prepare the bony scaffold, the MNPs release heat when insert into the magnetic field and control the tumor size which helps the treatment of cancer. In general, it can be concluded that the produced porous scaffold using 3D printing and freeze-drying technology can be used to replace broken bones with the 3D printed EC-PLA coated with 10 wt% akermanite bioceramic with sufficient mechanical and biological behavior for the orthopedic application.