Healing of Apical Periodontitis after Nonsurgical Treatment in Patients with Type 2 Diabetes

摘要

Introduction: The purpose of this prospective study was to compare the success of primary root canal treatment between type 2 diabetic and nondiabetic patients and to investigate the effect of periapical healing on glycated hemoglobin (HbA1 c) in type 2 diabetic patients with apical periodontitis. Methods: Sixty mandibular molars with necrotic pulps and apical radiolucency (size >= 2 mm x 2 mm) were included in the study. Based on the HbA1 c levels, patients were divided into 2 groups: type 2 diabetic (HbAlc >= 6.5%) and nondiabetic (HbAlc <6.5%). Forty-six teeth were evaluated at the 12-month follow-up time period. The primary outcome measure was the change in apical bone density as determined by the periapical index. Results: Both the diabetic and nondiabetic group depicted a significant reduction in the periapical score after endodontic treatment at the 12-month follow-up (P < .05). Significantly less periapical healing was observed in the diabetic group (43%) compared with the nondiabetic group (80%) at the 12-month follow-up (P < .05). HbAlc levels in the diabetic group increased at each follow-up after endodontic treatment. Conclusions: Diabetes mellitus may have a negative impact on the outcome of endodontic treatment in terms of periapical healing. Nonsurgical endodontic treatment did not improve HbA1 c levels in patients with type 2 diabetes.