Clinical study on the effect of simvastatin on the bone healing in elderly patients with femoral intertrochanteric fracture merged with type 2 diabetes mellitus

摘要

Objective:To explore the effect of simvastatin on the bone mineral density (BMD) and bone metabolism in elderly patients with femoral intertrochanteric fracture merged with type 2 diabetes mellitus (T2DM).Methods: A total of 120 patients with femoral intertrochanteric fracture merged with T2DM who were admitted in our hospital from June, 2014 to October, 2016 were included in the study and randomized into the observation group and the control group (n=60). The patients in the two groups were given minimally invasive PFNA, and blood sugar and blood pressure reducing. The patients in the control group were given alendronate sodium, 70 mg/time, 1 time/week. On this basis, the patients in the observation group were given simvastatin, 40 mg/time,1 time/every night. After 6-month treatment, the efficacy was evaluated. The morning fasting peripheral venous blood before and after treatment in the two groups was collected. The full automatic biochemical analyzer was used to detect the serum Ca, P, and GHb. ECLI was used to detect the serum OC and BAP. ELISA was used to detect the serum TRACP-5b and s-CTX. The dual energy X-ray absorptiomery was used to detect BMD level of the forearm, femoral neck, and anterial position of lumbar spine.Results:Ca, P, and GHb levels after treatment in the two groups were not significantly changed (P>0.05). BMD level of the forearm, femoral neck, and anterial position of lumbar spine after treatment in the observation group was significantly higher than that in the control group (P<0.05). OC and BAP levels after treatment in the observation group were significantly higher than those in the control group (P<0.05), while s-CTX and TRACP-5b levels were significantly lower than those in the control group (P<0.05).Conclusions:Simvastatin can significantly improve the bone metabolism abnormality in elderly patients with femoral intertrochanteric fracture merged with T2DM, enhance BMD, and promote the bone formation and fracture healing; therefore, it deserves to be widely recommended in the clinic.