History of methyl phosphoric esters: Hall, Weger, and Lossen.

摘要

Williamson serendipitously discovered (1851) a new and efficient way to produce ethers using ethyl iodide and potassium salts and in doing so elucidated the molecular mechanism behind ether formation. Before Williamson, the direct reaction between alcohol and acids was the only method of generating the elusive ethers synthesis of the first organophosphate ever, triethyl phosphate (TEP) in 1848. Based on the landmark work of Williamson, however, over the next thirty years or so numerous chemists managed to produce TEP and tetraethyl pyrophosphate (TEPP) using synthetic pathways of increasingly higher yield. With the "wood spirit