Discoid drug-induced lupus erythematosus induced by antitumor necrosis factor agents is a very rare subtype of cutaneous lupus: Three cases and literature review

摘要

Dear Editor, Drug-induced lupus erythematosus (DiLE) is a lupus-like autoimmune disorder, which usually occurs with chronic exposure to certain drugs and resolves after cessation of the culprit medication. The spectrum of DiLE constantly evolves with that of the pharmacopeia. in a recent study of 12 166 DILE identified from the WHO pharmacovigilance database, 118 drugs were identified. This study showed that since 2007, antitumor necrosis factor (anti-TNF) agents have been the drugs most commonly associated with systemic DiLE. Such as idiopathic lupus, DiLE can be classified in systemic and cutaneous DILE. Among cutaneous DiLE, subacute DiLE has been mostly reported. in a case-control study, anti-TNF agents were also associated with occurrence of subacute DiLE (odds ratio 8.0, 95% confidence interval 1.6-37.2). Discoid form of DiLE has been rarely reported. We report three cases of discoid DiLE induced by anti-TNF agents and we reviewed four cases previously published identified through a literature search from MEDLiNE/PubMed and we describe clinical, immunological, and pathological features, potential association with systemic DiLE and therapeutic management.