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Effects of neurotensin in amygdaloid spatial learning mechanisms.

机译:神经降压素在杏仁状空间学习机制中的作用。

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摘要

Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.
机译:神经降压素(NT)充当神经递质和/或神经调节剂,并在学习和奖励相关过程中发挥作用。杏仁核(CeA)的中央核参与记忆和学习机制的调节。在莫里斯水迷宫测试中,向大鼠显微注射NT或神经降压素受体1(NTS1)拮抗剂SR 48692(ANT)。 NT大大减少了逃逸潜伏期。 NT的作用被ANT预处理所阻断。我们的结果表明,在大鼠中CeA NT促进空间学习。我们澄清了NTS1参与了此操作。

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