4-Phosphatephenyl-modified glassy carbon electrode for real-time and simultaneous electrochemical monitoring of paracetamol and diclofenac release from electrospun nanofibers

摘要

An effective electrochemical platform was set up for the real-time and simultaneous monitoring of the kinetics of drug release from electrospun nanofibers. The method describes the development and utilization of a 4-phosphatephenyl (4-PP)-modified glassy carbon electrode (GCE). The modified electrode was used to monitor paracetamol (PCT) and/or diclofenac (DCF) release from electrospun nanofibers. The drug-loaded nanofibers were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Using differential pulse voltammetry (DPV), the modified electrode shows good sensitivity and selectivity for the simultaneous determination of PCT (1.87 mu M to 170 mM.) and DCF (0.37s-51.87 mu M). The release kinetics study reveals that the drug follows first order kinetics and that the mechanism of drug release was a diffusion-controlled type. No significant drug-polymer interactions were observed in the FTIR studies. The results obtained are promising, which demonstrates that the electrochemical method possesses the capability for the simultaneous detection of multiple molecules in a drug delivery system (DDS).