Reduced intensity conditioning allogeneic hematopoietic stem cell transplant could be beneficial to angioimmunoblastic T-cell lymphoma patients with hemophagocytic lymphohistiocytosis.

摘要

T-cell non-Hodgkin's lymphomas (NHLs) are a group of heterogeneous diseases with more aggressive behavior and dismal outcome than B-cell NHLs and account for less than 10% of the cases of aggressive NHLs in Western countries [1]. The outcome of T-cell NHL is even worse when it occurs in combination with hemophago-cytic lymphohistiocytosis (HLH); this combination presents with fever, cytopenia, liver dysfunction, hepatos-plenomegaly, hypertriglyceridemia, and hyperferritinemia [2, 3]. We report the case of a patient who had angioimmunoblastic T-cell lymphoma (AITL) and HLH and was successfully treated by allogeneic hematopoietic stem cell transplant (HSCT) with a reduced-intensity conditioning (RIC) regimen.